⊛⊛ ✺✧⎈⎈❉✹ψ✵✦⍟ψ★✸٭✧﹡⊛
⊛⊛ https://onwatchly.com/video-9743.html?utm_source=pedrofelipevelasco.blogia
⊛⊛ ψ✲⬆★✶✰♠≈⁕⇪✺♣✺★✫▲♢
Country: Canada
director: Sylvia Soska
1568 votes
genre: Horror, Sci-Fi
1 hours 47 min
As a dedicated vegetarian, these kind of movies are hilarious. Those craving for meat are indeed screwed up in the head.
No, seriously, this movie was fun to watch. I'm aware this is a remake and I haven't seen the original. I do however enjoy the work of the Soska sisters and wanted to see how they pull this one off. As I expected, they did a solid job. Not a masterpiece but certainly a far better movie than many more famous horror movies that are currently box office hits. Now I have a rabid craving for some vegetarian dish.
Was anyone else lost or was it just me. Last time I was this early, The Texans were up 24-0. I put achol in my pumpkins and had a squirrel fall out of a tree onto my head. Me:oh sweet this is a new horror movie starts trailer and see the word leave appear Me:k. 1 win & 1 nomination. See more awards » Edit Storyline What happens when you realize that to achieve your dreams you have to live a nightmare? Rose is a quiet, demure, unassuming woman in her looks and actions. Her dream is to become a famous designer in the fashion world, but a terrible accident leaves Rose scarred beyond recognition. She seeks out a radical untested stem cell treatment. The treatment is nothing short of a miracle and wallflower Rose turns into the belle of the ball. It all seems to good to be true. She is now everything she wanted to be. But everything in life comes at a price and this new found perfect life is no exception. Plot Summary | Add Synopsis Details Release Date: 13 December 2019 (USA) See more » Box Office Budget: $5, 000, 000 (estimated) See more on IMDbPro » Company Credits Technical Specs See full technical specs » Did You Know? Goofs Dr. Keloid says the accident punctured Rose's abdomen, but the bandages are on her chest. See more » Connections Remake of Rabid (1977) See more ».
| Simon Abrams December 13, 2019 “Rabid” definitely feels like a remake of a 1977 horror cheapy directed by a young David Cronenberg. Co-writer/director team Jen and Sylvia Soska, with the help of co-writer John Serge, have only superficially updated Cronenberg’s “Rabid, ” a B-movie about the dehumanizing effects of a vampire-like epidemic. The Soskas’ revamped “Rabid” is still worth seeing because they have a wickedly funny sense of humor, and a few winningly nasty ideas about how their obsessive characters would only grow more selfish during a crisis. But: the best parts of “Rabid” are often overshadowed by tired jokes about the cut-throat fashion industry (the movie’s heroine is a wannabe clothing designer), and the predatory nature of self-styled artists. There are a lot of promising ideas here, but none are developed so much that this remake feels essential. Advertisement “Rabid” begins with the first of a few endearing, but forgettable tributes to Cronenberg’s movies: a motorcycle almost spins out of control, like it does at the beginning of the original 1977 “Rabid. ” The motorcycle is driven by Rose ( Laura Vandervoort), a scarred fashion designer who’s initially defined by how defensive she feels at work (ex: she’s a vegetarian, eek! ). Rose feels singled out by her blowhard boss Gunter ( Mackenzie Gray), a stereotypically oily Euro-trash aesthete who would fit right into “ Zoolander. ” Rose is also mocked by her peers, like Bev and Ellie (the Soskas), who pick on the blemish covering Rose’s forehead (“ Scarface ”) whenever they’re not snorting cocaine or physically bumping Rose out of the way in their haste to enter a popular Canadian night club. “Rabid” isn’t a period piece, though it sometimes feels like one. Soon enough, Rose inadvertently succeeds at getting into a motorcycle accident, leaving her horribly maimed; her jaw is wired shut, and some of her intestines have been ripped out. Rose’s recovery is sped up considerably by aspiring model and BFF Chelsea ( Hanneke Talbot), as well as some radical reconstructive surgery from Dr. William Burroughs ( Ted Atherton). But, while Rose is now turning heads—including Gunter, who gives her a rare opportunity to develop her clothing designs for his “Schadenfreude” collection—she’s also ripping out the jugulars of insecure alpha predators like night-club brute Billy (CM Punk) or narcissist soap opera star Dominic ( Stephen Huszar). Because Rose, like Chambers’s character in the original “Rabid, ” has contracted a weird strain of vampire-like bloodlust, an association that’s spelled out in the scene where Dr. Burroughs listens to the other William Burroughs read a passage about vampires in his spoken-word piece, “Advice for Young People. ” That allusion is a bit too blunt to be clever, but it is kind of charming as a side-long tribute to Cronenberg’s own “ Naked Lunch ” adaptation. Less thrilling: heavy-handed dialogue that’s neither provocative nor cruel enough to be effective as sandwich-board speechifying. Gunter’s dialogue is especially bad, though Gray puts an appropriately loopy, Udo Kier-esque spin on lines like, "I do not mean to die for fashion, but this fashion is to die for, mmm. ” Other declarative statements are not as easily salvaged, like when Rose tells hunky, pure-hearted photographer love interest Brad Hart ( Benjamin Hollingsworth) that “I just love the way that the clothes make me feel. You can literally be anybody, become any thing. It's like armor: when you walk out the door, you're arming yourself. " His response—“For me, true beauty lies in the things we have yet to uncover”—wouldn’t be so unfortunate if the Soskas viciously laid into him more later on (or her, for that matter). There are a number of dark, and grimly funny ideas in the Soskas’ “Rabid, ” but their vision isn’t strong enough to tie them all together. Rose and Beverly’s relationship is especially under-developed, which robs a climactic moment of its slam-the-brakes power. The movie’s irruptive sense of gross-out humor also never really seems fitting given the goofy targets of the Soskas’ derision. One minute the characters are struggling to explain—at length—how they’re feeling, and then the next minute, there’s a monstrous appendage coming out of Rose’s head (weirdly reminiscent of a certain infamous Jamaa Fanaka movie). I wanted more where that came from, or maybe a more thoughtful gutting of the hand-me-down tropes that Cronenberg previously attacked. But the Soskas’ signature fascination with transhumanism and body modification doesn’t travel very far here (then again, it doesn’t go far in Cronenberg’s “Rabid, ” either). The Soskas’ are, however, smart to play up the melodramatic elements of Rose’s story, so that she’s more like Carrie White (Cronenberg originally hoped to cast Sissy Spacek because of her performance in “Carrie”), just as they consummately play up Dr. Burroughs’s Frankensteinian ambition as a riff on the blinding hubris that motivates Oliver Reed ’s Hal Raglan in Cronenberg’s “ The Brood. ” But, while “Rabid” is a faithful homage, it doesn’t hang together the way it should. Reveal Comments comments powered by.
Looks good want to go see it🤔. Boris- san. To everyone here who doesn't know better: That weird strained yowling the smaller dog is making is often a sign of rabies. Rabies paralyzes the vocal chords, causing this unusual sound. Paired with it's sickly look and odd behavior, this animal may have rabies. Considering this channel is an animal clinic, I don't think they would lie about a dog being rabid either. Use your brains, and do your research please.
Rabies A dog with rabies in the paralytic (post-furious) stage Specialty Infectious disease Symptoms Fever, fear of water, confusion, excessive salivation, hallucinations, trouble sleeping, paralysis, coma [1] [2] Causes Rabies virus, Australian bat lyssavirus [3] Prevention Rabies vaccine, animal control, rabies immunoglobulin [1] Prognosis Nearly always death if symptoms start to manifest [1] Deaths 17, 400 (2015) [4] Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. [1] Early symptoms can include fever and tingling at the site of exposure. [1] These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. [1] Once symptoms appear, the result is nearly always death. [1] The time period between contracting the disease and the start of symptoms is usually one to three months, but can vary from less than one week to more than one year. [1] The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system. [5] Rabies is caused by lyssaviruses, including the rabies virus and Australian bat lyssavirus. [3] It is spread when an infected animal bites or scratches a human or other animal. [1] Saliva from an infected animal can also transmit rabies if the saliva comes into contact with the eyes, mouth, or nose. [1] Globally, dogs are the most common animal involved. [1] In countries where dogs commonly have the disease, more than 99% of rabies cases are the direct result of dog bites. [6] In the Americas, bat bites are the most common source of rabies infections in humans, and less than 5% of cases are from dogs. [1] [6] Rodents are very rarely infected with rabies. [6] The disease can be diagnosed only after the start of symptoms. [1] Animal control and vaccination programs have decreased the risk of rabies from dogs in a number of regions of the world. [1] Immunizing people before they are exposed is recommended for those at high risk, including those who work with bats or who spend prolonged periods in areas of the world where rabies is common. [1] In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms. [1] Washing bites and scratches for 15 minutes with soap and water, povidone-iodine, or detergent may reduce the number of viral particles and may be somewhat effective at preventing transmission. [1] [7] As of 2016, only fourteen people had survived a rabies infection after showing symptoms. [8] [9] [10] Rabies caused about 17, 400 human deaths worldwide in 2015. [4] More than 95% of human deaths from rabies occur in Africa and Asia. [1] About 40% of deaths occur in children under the age of 15. [11] Rabies is present in more than 150 countries and on all continents but Antarctica. [1] More than 3 billion people live in regions of the world where rabies occurs. [1] A number of countries, including Australia and Japan, as well as much of Western Europe, do not have rabies among dogs. [12] [13] Many Pacific islands do not have rabies at all. [13] It is classified as a neglected tropical disease. [14] Signs and symptoms The period between infection and the first symptoms (incubation period) is typically 1–3 months in humans. [15] This period may be as short as four days or longer than six years, depending on the location and severity of the wound and the amount of virus introduced. [15] Initial symptoms of rabies are often nonspecific such as fever and headache. [15] As rabies progresses and causes inflammation of the brain and meninges, symptoms can include slight or partial paralysis, anxiety, insomnia, confusion, agitation, abnormal behavior, paranoia, terror, and hallucinations. [5] [15] The person may also have fear of water. [1] The symptoms eventually progress to delirium, and coma. [5] [15] Death usually occurs 2 to 10 days after first symptoms. Survival is almost unknown once symptoms have presented, even with intensive care. [15] [16] Fear of water Hydrophobia ("fear of water") is the historic name for rabies. [17] It refers to a set of symptoms in the later stages of an infection in which the person has difficulty swallowing, shows panic when presented with liquids to drink, and cannot quench their thirst. Any mammal infected with the virus may demonstrate hydrophobia. [18] Saliva production is greatly increased, and attempts to drink, or even the intention or suggestion of drinking, may cause excruciatingly painful spasms of the muscles in the throat and larynx. This can be attributed to the fact that the virus multiplies and assimilates in the salivary glands of the infected animal with the effect of further transmission through biting. The ability to transmit the virus would decrease significantly if the infected individual could swallow saliva and water. [19] Hydrophobia is commonly associated with furious rabies, which affects 80% of rabies-infected people. The remaining 20% may experience a paralytic form of rabies that is marked by muscle weakness, loss of sensation, and paralysis; this form of rabies does not usually cause fear of water. [18] Cause Rendering of the rabies virus Rabies is caused by a number of lyssaviruses including the rabies virus and Australian bat lyssavirus. [3] Duvenhage lyssavirus may cause a rabies-like infection. [20] The rabies virus is the type species of the Lyssavirus genus, in the family Rhabdoviridae, order Mononegavirales. Lyssavirions have helical symmetry, with a length of about 180 nm and a cross-section of about 75 nm. [21] These virions are enveloped and have a single-stranded RNA genome with negative sense. The genetic information is packed as a ribonucleoprotein complex in which RNA is tightly bound by the viral nucleoprotein. The RNA genome of the virus encodes five genes whose order is highly conserved: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and the viral RNA polymerase (L). [22] Once within a muscle or nerve cell, the virus undergoes replication. The trimeric spikes on the exterior of the membrane of the virus interact with a specific cell receptor, the most likely one being the acetylcholine receptor. The cellular membrane pinches in a procession known as pinocytosis and allows entry of the virus into the cell by way of an endosome. The virus then uses the acidic environment, which is necessary, of that endosome and binds to its membrane simultaneously, releasing its five proteins and single strand RNA into the cytoplasm. [23] The L protein then transcribes five mRNA strands and a positive strand of RNA all from the original negative strand RNA using free nucleotides in the cytoplasm. These five mRNA strands are then translated into their corresponding proteins (P, L, N, G and M proteins) at free ribosomes in the cytoplasm. Some proteins require post-translative modifications. For example, the G protein travels through the rough endoplasmic reticulum, where it undergoes further folding, and is then transported to the Golgi apparatus, where a sugar group is added to it ( glycosylation). [23] When there are enough viral proteins, the viral polymerase will begin to synthesize new negative strands of RNA from the template of the positive strand RNA. These negative strands will then form complexes with the N, P, L and M proteins and then travel to the inner membrane of the cell, where a G protein has embedded itself in the membrane. The G protein then coils around the N-P-L-M complex of proteins taking some of the host cell membrane with it, which will form the new outer envelope of the virus particle. The virus then buds from the cell. [23] From the point of entry, the virus is neurotropic, traveling along the neural pathways into the central nervous system. The virus usually first infects muscle cells close to the site of infection, where they are able to replicate without being 'noticed' by the host's immune system. Once enough virus has been replicated, they begin to bind to acetylcholine receptors at the neuromuscular junction. [24] The virus then travels through the nerve cell axon via retrograde transport, as its P protein interacts with dynein, a protein present in the cytoplasm of nerve cells. Once the virus reaches the cell body it travels rapidly to the central nervous system (CNS), replicating in motor neurons and eventually reaching the brain. [5] After the brain is infected, the virus travels centrifugally to the peripheral and autonomic nervous systems, eventually migrating to the salivary glands, where it is ready to be transmitted to the next host. [25]: 317 Transmission All warm-blooded species, including humans, may become infected with the rabies virus and develop symptoms. Birds were first artificially infected with rabies in 1884; however, infected birds are largely, if not wholly, asymptomatic, and recover. [26] Other bird species have been known to develop rabies antibodies, a sign of infection, after feeding on rabies-infected mammals. [27] [28] The virus has also adapted to grow in cells of cold-blooded vertebrates. [29] [30] Most animals can be infected by the virus and can transmit the disease to humans. Infected bats, [31] [32] monkeys, raccoons, foxes, skunks, cattle, wolves, coyotes, dogs, cats, and mongooses (normally either the small Asian mongoose or the yellow mongoose) [33] present the greatest risk to humans. Rabies may also spread through exposure to infected bears, domestic farm animals, groundhogs, weasels, and other wild carnivorans. However, lagomorphs, such as hares and rabbits, and small rodents such as chipmunks, gerbils, guinea pigs, hamsters, mice, rats, and squirrels, are almost never found to be infected with rabies and are not known to transmit rabies to humans. [34] Bites from mice, rats, or squirrels rarely require rabies prevention because these rodents are typically killed by any encounter with a larger, rabid animal, and would, therefore, not be carriers. [35] The Virginia opossum is resistant but not immune to rabies. [36] The virus is usually present in the nerves and saliva of a symptomatic rabid animal. [37] [38] The route of infection is usually, but not always, by a bite. In many cases, the infected animal is exceptionally aggressive, may attack without provocation, and exhibits otherwise uncharacteristic behavior. [39] This is an example of a viral pathogen modifying the behavior of its host to facilitate its transmission to other hosts. Transmission between humans is extremely rare. A few cases have been recorded through transplant surgery. [40] The only well-documented cases of rabies caused by human-to-human transmission occurred among eight recipients of transplanted corneas and among three recipients of solid organs. [41] In addition to transmission from cornea and organ transplants, bite and non-bite exposures inflicted by infected humans could theoretically transmit rabies, but no such cases have been documented, since infected humans are usually hospitalized and necessary precautions taken. Casual contact, such as touching a person with rabies or contact with non-infectious fluid or tissue (urine, blood, feces) does not constitute an exposure and does not require post-exposure prophylaxis. Additionally, as the virus is present in sperm or vaginal secretions, spread through sex may be possible. [42] After a typical human infection by bite, the virus enters the peripheral nervous system. It then travels along the afferent nerves toward the central nervous system. [43] During this phase, the virus cannot be easily detected within the host, and vaccination may still confer cell-mediated immunity to prevent symptomatic rabies. When the virus reaches the brain, it rapidly causes encephalitis, the prodromal phase, which is the beginning of the symptoms. Once the patient becomes symptomatic, treatment is almost never effective and mortality is over 99%. Rabies may also inflame the spinal cord, producing transverse myelitis. [44] [45] Diagnosis Rabies can be difficult to diagnose because, in the early stages, it is easily confused with other diseases or with aggressiveness. [46] The reference method for diagnosing rabies is the fluorescent antibody test (FAT), an immunohistochemistry procedure, which is recommended by the World Health Organization (WHO). [47] The FAT relies on the ability of a detector molecule (usually fluorescein isothiocyanate) coupled with a rabies-specific antibody, forming a conjugate, to bind to and allow the visualisation of rabies antigen using fluorescent microscopy techniques. Microscopic analysis of samples is the only direct method that allows for the identification of rabies virus-specific antigen in a short time and at a reduced cost, irrespective of geographical origin and status of the host. It has to be regarded as the first step in diagnostic procedures for all laboratories. Autolysed samples can, however, reduce the sensitivity and specificity of the FAT. [48] The RT PCR assays proved to be a sensitive and specific tool for routine diagnostic purposes, [49] particularly in decomposed samples [50] or archival specimens. [51] The diagnosis can be reliably made from brain samples taken after death. The diagnosis can also be made from saliva, urine, and cerebrospinal fluid samples, but this is not as sensitive or reliable as brain samples. [48] Cerebral inclusion bodies called Negri bodies are 100% diagnostic for rabies infection but are found in only about 80% of cases. [21] If possible, the animal from which the bite was received should also be examined for rabies. [52] Some light microscopy techniques may also be used to diagnose rabies at a tenth of the cost of traditional fluorescence microscopy techniques, allowing identification of the disease in less-developed countries. [53] A test for rabies, known as LN34, is easier to run on a dead animal's brain and might help determine who does and does not need post-exposure prevention. [54] The test was developed by the CDC in 2018. [54] Differential diagnosis The differential diagnosis in a case of suspected human rabies may initially include any cause of encephalitis, in particular infection with viruses such as herpesviruses, enteroviruses, and arboviruses such as West Nile virus. The most important viruses to rule out are herpes simplex virus type one, varicella zoster virus, and (less commonly) enteroviruses, including coxsackieviruses, echoviruses, polioviruses, and human enteroviruses 68 to 71. [55] New causes of viral encephalitis are also possible, as was evidenced by the 1999 outbreak in Malaysia of 300 cases of encephalitis with a mortality rate of 40% caused by Nipah virus, a newly recognized paramyxovirus. [56] Likewise, well-known viruses may be introduced into new locales, as is illustrated by the outbreak of encephalitis due to West Nile virus in the eastern United States. [57] Epidemiologic factors, such as season, geographic location, and the patient's age, travel history, and possible exposure to bites, rodents, and ticks, may help direct the diagnosis. Prevention Almost all human cases of rabies were fatal until a vaccine was developed in 1885 by Louis Pasteur and Émile Roux. Their original vaccine was harvested from infected rabbits, from which the virus in the nerve tissue was weakened by allowing it to dry for five to ten days. [58] Similar nerve tissue-derived vaccines are still used in some countries, as they are much cheaper than modern cell culture vaccines. [59] The human diploid cell rabies vaccine was started in 1967. Less expensive purified chicken embryo cell vaccine and purified vero cell rabies vaccine are now available. [52] A recombinant vaccine called V-RG has been used in Belgium, France, Germany, and the United States to prevent outbreaks of rabies in undomesticated animals. [60] Immunization before exposure has been used in both human and nonhuman populations, where, as in many jurisdictions, domesticated animals are required to be vaccinated. [61] The Missouri Department of Health and Senior Services Communicable Disease Surveillance 2007 Annual Report states the following can help reduce the risk of contracting rabies: [62] Vaccinating dogs, cats, and ferrets against rabies Keeping pets under supervision Not handling wild animals or strays Contacting an animal control officer upon observing a wild animal or a stray, especially if the animal is acting strangely If bitten by an animal, washing the wound with soap and water for 10 to 15 minutes and contacting a healthcare provider to determine if post-exposure prophylaxis is required 28 September is World Rabies Day, which promotes the information, prevention, and elimination of the disease. [63] Vaccinating other animals In Asia and in parts of the Americas and Africa, dogs remain the principal host. Mandatory vaccination of animals is less effective in rural areas. Especially in developing countries, pets may not be privately kept and their destruction may be unacceptable. Oral vaccines can be safely distributed in baits, a practice that has successfully reduced rabies in rural areas of Canada, France, and the United States. In Montreal, Quebec, Canada, baits are successfully used on raccoons in the Mount-Royal Park area. Vaccination campaigns may be expensive, and cost-benefit analysis suggests baits may be a cost-effective method of control. [64] In Ontario, a dramatic drop in rabies was recorded when an aerial bait-vaccination campaign was launched. [65] The number of recorded human deaths from rabies in the United States has dropped from 100 or more annually in the early 20th century to one or two per year due to widespread vaccination of domestic dogs and cats and the development of human vaccines and immunoglobulin treatments. Most deaths now result from bat bites, which may go unnoticed by the victim and hence untreated. [66] Treatment After exposure Treatment after exposure can prevent the disease if given within 10 days. The rabies vaccine is 100% effective if given early, and still has a chance of success if delivery is delayed. [21] [23] [67] Every year, more than 15 million people get vaccination after potential exposure. While this works well, the cost is significant. [68] In the US it is recommended people receive one dose of human rabies immunoglobulin (HRIG) and four doses of rabies vaccine over a 14-day period. [69] HRIG is expensive and makes up most of the cost of post exposure treatment, ranging as high as several thousand dollars. [70] As much as possible of this dose should be injected around the bites, with the remainder being given by deep intramuscular injection at a site distant from the vaccination site. [23] People who have previously been vaccinated against rabies do not need to receive the immunoglobulin, only the postexposure vaccinations on days 0 and 3. [71] The side effects of modern cell-based vaccines are similar to flu shots. The old nerve-tissue-based vaccination required multiple injections into the abdomen with a large needle but is inexpensive. [52] It is being phased out and replaced by affordable World Health Organization intradermal-vaccination regimens. [52] Intramuscular vaccination should be given into the deltoid, not the gluteal area, which has been associated with vaccination failure due to injection into fat rather than muscle. In children less than a year old, the lateral thigh is recommended. [72] Thoroughly washing the wound as soon as possible with soap and water for approximately five minutes is effective in reducing the number of viral particles. [73] Povidone-iodine or alcohol is then recommended to reduce the virus further. [74] Awakening to find a bat in the room, or finding a bat in the room of a previously unattended child or mentally disabled or intoxicated person, is an indication for post-exposure prophylaxis (PEP). The recommendation for the precautionary use of PEP in bat encounters where no contact is recognized has been questioned in the medical literature, based on a cost–benefit analysis. [75] However, a 2002 study has supported the protocol of precautionary administering of PEP where a child or mentally compromised individual has been alone with a bat, especially in sleep areas, where a bite or exposure may occur with the victim being unaware. [76] After onset A treatment known as the Milwaukee protocol, which involves putting a person into a chemically induced coma and using antiviral medications, has been proposed but subsequently found not to be useful. [77] It initially came into use in 2003, following Jeanna Giese, a teenager from Wisconsin, becoming the first person known to have survived rabies without preventive treatments before symptom onset. [78] [79] She, however, already had antibodies against rabies when she initially arrived at hospital. [77] While this treatment has been tried multiple times more, there have been no further cases of survival. [77] The protocol has since been assessed as an ineffective treatment with concerns related to the costs and ethics of its use. [77] [80] Prognosis Vaccination after exposure, PEP, is highly successful in preventing the disease. [67] In unvaccinated humans, rabies is almost always fatal after neurological symptoms have developed. [81] Epidemiology Deaths from rabies per million persons in 2012 0 1 2–4 5–9 10–17 18–69 Map of rabies-free countries and territories In 2010, an estimated 26, 000 people died from rabies, down from 54, 000 in 1990. [82] The majority of the deaths occurred in Asia and Africa. [81] As of 2015, India, followed by China (approximately 6, 000), and the Democratic Republic of the Congo (5, 600) had the most cases. [83] A 2015 collaboration between the World Health Organization, World Organization of Animal Health (OIE), Food and Agriculture Organization of the United Nation (FAO), and Global Alliance for Rabies Control has a goal of eliminating deaths from rabies by 2030. [84] India India has the highest rate of human rabies in the world, primarily because of stray dogs, [85] whose number has greatly increased since a 2001 law forbade the killing of dogs. [86] Effective control and treatment of rabies in India is hindered by a form of mass hysteria known as puppy pregnancy syndrome (PPS). Dog bite victims with PPS, male as well as female, become convinced that puppies are growing inside them, and often seek help from faith healers rather than medical services. [87] An estimated 20, 000 people die every year from rabies in India, more than a third of the global total. [86] Australia The rabies virus survives in widespread, varied, rural animal reservoirs. Despite Australia's official rabies-free status, [88] Australian bat lyssavirus (ABLV), discovered in 1996, is a strain of rabies prevalent in native bat populations. There have been three human cases of ABLV in Australia, all of them fatal. United States Rabies cases in humans and domestic animals — United States, 1938–2018 From 1960 to 2018, a total of 125 human rabies cases were reported in the United States; 36 (28%) were attributed to dog bites during international travel. [89] Among the 89 infections acquired in the United States, 62 (70%) were attributed to bats. [89] While canine-specific rabies does not circulate among dogs, about a hundred dogs become infected from other wildlife per year in the US. [90] [91] Rabies is common among wild animals in the United States. Bats, raccoons, skunks and foxes account for almost all reported cases (98% in 2009). Rabid bats are found in all 48 contiguous states. Other reservoirs are more limited geographically; for example, the raccoon rabies virus variant is only found in a relatively narrow band along the East Coast. Due to a high public awareness of the virus, efforts at vaccination of domestic animals and curtailment of feral populations, and availability of postexposure prophylaxis, incidence of rabies in humans is very rare. A total of 49 cases of the disease was reported in the country between 1995 and 2011; of these, 11 are thought to have been acquired abroad. Almost all domestically acquired cases are attributed to bat bites. [92] Europe Either no or very few cases of rabies are reported each year in Europe; cases are contracted both during travel and in Europe. [93] In Switzerland the disease was virtually eliminated after scientists placed chicken heads laced with live attenuated vaccine in the Swiss Alps. [65] The foxes of Switzerland, proven to be the main source of rabies in the country, ate the chicken heads and immunized themselves. [65] [94] Italy, after being declared rabies-free from 1997 to 2008, has witnessed a reemergence of the disease in wild animals in the Triveneto regions ( Trentino-Alto Adige/Südtirol, Veneto and Friuli-Venezia Giulia), due to the spreading of an epidemic in the Balkans that also affected Austria. An extensive wild animal vaccination campaign eliminated the virus from Italy again, and it regained the rabies-free country status in 2013, the last reported case of rabies being reported in a red fox in early 2011. [95] [96] Great Britain has been free of rabies since the beginning of the twentieth century except for a rabies-like virus in a few Daubenton's bats; there has been one, fatal, case of transmission to a human. There have been four deaths from rabies, transmitted abroad by dog bite, since 2000. The last infection in the UK occurred in 1922, and the last death from indigenous rabies was in 1902. [97] [98] Unlike the other countries of Europe it is protected by being an island, and by strict quarantine procedures. Mexico Mexico was certified by the World Health Organization as free of dog-transmitted rabies in 2019, since no case of dog-human transmission has been recorded in two years. [99] History Rabies has been known since around 2000 BC. [100] The first written record of rabies is in the Mesopotamian Codex of Eshnunna (circa 1930 BC), which dictates that the owner of a dog showing symptoms of rabies should take preventive measure against bites. If another person were bitten by a rabid dog and later died, the owner was heavily fined. [101] Ineffective folk remedies abounded in the medical literature of the ancient world. The physician Scribonius Largus prescribed a poultice of cloth and hyena skin; Antaeus recommended a preparation made from the skull of a hanged man. [102] Rabies appears to have originated in the Old World, the first epizootic in the New World occurring in Boston in 1768. [103] It spread from there, over the next few years, to various other states, as well as to the French West Indies, eventually becoming common all across North America. Rabies was considered a scourge for its prevalence in the 19th century. In France and Belgium, where Saint Hubert was venerated, the " St Hubert's Key " was heated and applied to cauterize the wound. By an application of magical thinking, dogs were branded with the key in hopes of protecting them from rabies. The fear of rabies was almost irrational, due to the number of vectors (mostly rabid dogs) and the absence of any efficacious treatment. It was not uncommon for a person bitten by a dog merely suspected of being rabid to commit suicide or to be killed by others. [104] In ancient times the attachment of the tongue (the lingual frenulum, a mucous membrane) was cut and removed as this was where rabies was thought to originate. This practice ceased with the discovery of the actual cause of rabies. [25] Louis Pasteur's 1885 nerve tissue vaccine was successful, and was progressively improved to reduce often severe side-effects. [15] In modern times, the fear of rabies has not diminished, and the disease and its symptoms, particularly agitation, have served as an inspiration for several works of zombie or similarly-themed fiction, often portraying rabies as having mutated into a stronger virus which fills humans with murderous rage or incurable illness, bringing about a devastating, widespread pandemic. [105] Etymology The term is derived from the Latin rabies, "madness". [106] This, in turn, may be related to the Sanskrit rabhas, "to rage". [107] The Greeks derived the word lyssa, from lud or "violent"; this root is used in the genus name of the rabies virus, Lyssavirus. [104] Other animals Rabies is infectious to mammals; three stages of central nervous system infection are recognized. The first stage is a one- to three-day period characterized by behavioral changes and is known as the prodromal stage. The second is the excitative stage, which lasts three to four days. This stage is often known as "furious rabies" for the tendency of the affected animal to be hyper-reactive to external stimuli and bite at anything near. The third is the paralytic stage and is caused by damage to motor neurons. Incoordination is seen, owing to rear limb paralysis, and drooling and difficulty swallowing is caused by paralysis of facial and throat muscles. Death is usually caused by respiratory arrest. [108] Research The outer shell of the rabies virus, stripped of its RNA contents and thus unable to cause disease, may be used as a vector for the delivery of unrelated genetic material in a research setting. It has the advantage over other pseudotyping methods for gene delivery that the cell targeting ( tissue tropism) is more specific for the central nervous system, a difficult-to-reach site, obviating the need for invasive delivery methods. It is also capable of infecting neighboring "upstream" cells, moving from one cell to axons of the next at synapses, and is thus used for retrograde tracing in neuronal circuits. [109] Evidence indicates artificially increasing the permeability of the blood–brain barrier, which normally does not allow most immune cells across, promotes viral clearance. [110] [111] See also Global Alliance for Rabies Control Rabies in Haiti Rabies in popular culture World Rabies Day References ^ a b c d e f g h i j k l m n o p q r s t u "Rabies Fact Sheet N°99". World Health Organization. July 2013. Archived from the original on 1 April 2014. Retrieved 28 February 2014. ^ "Rabies - Symptoms and causes". Mayo Clinic. Retrieved 9 April 2018. ^ a b c "Rabies, Australian bat lyssavirus and other lyssaviruses". The Department of Health. December 2013. Archived from the original on 4 March 2014. Retrieved 1 March 2014. ^ a b Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality and Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi: 10. 1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281. ^ a b c d Cotran RS, Kumar V, Fausto N (2005). Robbins and Cotran Pathologic Basis of Disease (7th ed. ). Elsevier/Saunders. p. 1375. ISBN 978-0-7216-0187-8. ^ a b c Tintinalli JE (2010). Emergency Medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli)). McGraw-Hill. pp. Chapter 152. ISBN 978-0-07-148480-0. ^ Wunner WH (2010). Rabies: Scientific Basis of the Disease and Its Management. Academic Press. p. 556. ISBN 9780080550091. ^ Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J (May 2013). "Human rabies: neuropathogenesis, diagnosis, and management". The Lancet. Neurology. 12 (5): 498–513. 1016/s1474-4422(13)70038-3. PMID 23602163. ^ "UC Davis Children's Hospital patient becomes third person in U. S. to survive rabies". UC Davis Medical Center. Archived from the original on 21 May 2012. Retrieved 3 May 2012. ^ Manoj S, Mukherjee A, Johri S, Kumar KV (2016). "Recovery from rabies, a universally fatal disease". Military Medical Research. 3 (1): 21. 1186/s40779-016-0089-y. PMC 4947331. PMID 27429788. ^ "Rabies: The Facts" (PDF). Archived (PDF) from the original on 24 February 2017. Retrieved 24 February 2017. ^ WHO Expert Consultation on Rabies: second report (PDF) (2 ed. Geneva: WHO. 2013. p. 3. ISBN 9789241209823. Archived (PDF) from the original on 20 October 2014. ^ a b "Rabies-Free Countries and Political Units". CDC. Archived from the original on 5 March 2014. Retrieved 8 May 2019. ^ "Neglected Tropical Diseases".. 6 June 2011. Archived from the original on 4 December 2014. Retrieved 28 November 2014. ^ a b c d e f g Giesen A, Gniel D, Malerczyk C (March 2015). "30 Years of rabies vaccination with Rabipur: a summary of clinical data and global experience". Expert Review of Vaccines (Review). 14 (3): 351–67. 1586/14760584. 2015. 1011134. PMID 25683583. ^ Rupprecht CE, Willoughby R, Slate D (December 2006). "Current and future trends in the prevention, treatment and control of rabies". Expert Review of Anti-Infective Therapy. 4 (6): 1021–38. 1586/14787210. 4. 6. 1021. PMID 17181418. ^ Cliff AD, Haggett P, Smallman-Raynor M (2004). World atlas of epidemic diseases. London: Arnold. p. 51. ISBN 9780340761717. ^ a b "Symptoms of rabies".. 12 June 2012. Archived from the original on 14 September 2014. Retrieved 3 September 2014. ^ "Rabies".. Archived from the original on 3 September 2014. ^ van Thiel PP, de Bie RM, Eftimov F, Tepaske R, Zaaijer HL, van Doornum GJ, et al. (July 2009). "Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs". PLoS Neglected Tropical Diseases. 3 (7): e428. 1371/. PMC 2710506. PMID 19636367. ^ a b c Drew WL (2004). "Chapter 41: Rabies". In Ryan KJ, Ray CG (eds. Sherris Medical Microbiology (4th ed. McGraw Hill. pp. 597–600. ISBN 978-0-8385-8529-0. ^ Finke S, Conzelmann KK (August 2005). "Replication strategies of rabies virus". Virus Research. 111 (2): 120–31. 1016/rusres. 2005. 04. 004. PMID 15885837. ^ a b c d e "Rabies Post-Exposure Prophylaxis". Centers for Disease Control and Prevention (CDC). 23 December 2009. Archived from the original on 1 February 2010. Retrieved 30 January 2010. ^ Gluska S, Zahavi EE, Chein M, Gradus T, Bauer A, Finke S, Perlson E (August 2014). "Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery". PLoS Pathogens. 10 (8): e1004348. PMC 4148448. PMID 25165859. ^ a b Baer G (1991). The Natural History of Rabies. CRC Press. ISBN 9780849367601. Retrieved 31 October 2011. ^ Shannon LM, Poulton JL, Emmons RW, Woodie JD, Fowler ME (April 1988). "Serological survey for rabies antibodies in raptors from California". Journal of Wildlife Diseases. 24 (2): 264–7. 7589/0090-3558-24. 2. 264. PMID 3286906. ^ Gough PM, Jorgenson RD (July 1976). "Rabies antibodies in sera of wild birds". 12 (3): 392–5. 7589/0090-3558-12. 3. 392. PMID 16498885. ^ Jorgenson RD, Gough PM, Graham DL (July 1976). "Experimental rabies in a great horned owl". 12 (3): 444–7. 444. PMID 16498892. ^ Wong D. "Rabies". Wong's Virology. Archived from the original on 3 December 2008. Retrieved 19 March 2009. ^ Campbell JB, Charlton K (1988). Developments in Veterinary Virology: Rabies. Springer. p. 48. ISBN 978-0-89838-390-4. ^ Pawan JL (1959). "The transmission of paralytic rabies in Trinidad by the vampire bat (Desmodus rotundus murinus Wagner". Caribbean Medical Journal. 21: 110–36. PMID 13858519. ^ Pawan JL (1959). "Rabies in the vampire bat of Trinidad, with special reference to the clinical course and the latency of infection". 21: 137–56. PMID 14431118. ^ Taylor PJ (December 1993). "A systematic and population genetic approach to the rabies problem in the yellow mongoose (Cynictis penicillata)". The Onderstepoort Journal of Veterinary Research. 60 (4): 379–87. PMID 7777324. ^ "Rabies. Other Wild Animals: Terrestrial carnivores: raccoons, skunks and foxes". Archived from the original on 20 December 2010. Retrieved 23 December 2010. ^ Anderson J, Frey R (2006). In Fundukian LJ (ed. Gale Encyclopedia of Medicine (3rd ed. ). ^ McRuer DL, Jones KD (May 2009). "Behavioral and nutritional aspects of the Virginian opossum (Didelphis virginiana)". The Veterinary Clinics of North America. Exotic Animal Practice. 12 (2): 217–36, viii. 1016/. PMID 19341950. ^ The Merck Manual (11th ed. 1983. p. 183. ^ The Merck manual of Medical Information (Second Home ed. 2003. p. 484. ^ Turton J (2000). "Rabies: a killer disease". National Department of Agriculture. Archived from the original on 23 September 2006. ^ Srinivasan A, Burton EC, Kuehnert MJ, Rupprecht C, Sutker WL, Ksiazek TG, et al. (March 2005). "Transmission of rabies virus from an organ donor to four transplant recipients". The New England Journal of Medicine. 352 (11): 1103–11. 1056/NEJMoa043018. PMID 15784663. ^ "Human Rabies Prevention --- United States, 2008 Recommendations of the Advisory Committee on Immunization Practices". Centers for Disease Control and Prevention. 23 May 2008. Retrieved 11 February 2020. ^ Archived 24 September 2016 at the Wayback Machine ^ Jackson AC, Wunner WH (2002). Rabies. p. 290. ISBN 978-0-12-379077-4. Archived from the original on 8 January 2014. ^ Lynn DJ, Newton HB, Rae-Grant AD (2012). The 5-Minute Neurology Consult. Lippincott Williams & Wilkins. pp. 414–. ISBN 978-1-4511-0012-9. ^ Davis LE, King MK, Schultz JL (15 June 2005). Fundamentals of neurologic disease. Demos Medical Publishing. p. 73. ISBN 978-1-888799-84-2. Archived from the original on 8 January 2014. ^ Kahn CM, Line S, eds. (2010). The Merck Veterinary Manual (10th ed. Kendallville, Indiana: Courier Kendallville, Inc. p. 1193. ISBN 978-0-911910-93-3. ^ Dean DJ, Abelseth MK (1973). "Ch. 6: The fluorescent antibody test". In Kaplan MM, Koprowski H (eds. Laboratory techniques in rabies. Monograph series. 23 (3rd ed. p. 73. ^ a b Fooks AR, Johnson N, Freuling CM, Wakeley PR, Banyard AC, McElhinney LM, et al. (September 2009). "Emerging technologies for the detection of rabies virus: challenges and hopes in the 21st century". 3 (9): e530. PMC 2745658. PMID 19787037. ^ Tordo N, Bourhy H, Sacramento D (1994). 10: PCR technology for lyssavirus diagnosis". In Clewley JP (ed. The Polymerase Chain Reaction (PCR) for Human Viral Diagnosis. pp. 125–145. ISBN 978-0-8493-4833-4. ^ David D, Yakobson B, Rotenberg D, Dveres N, Davidson I, Stram Y (June 2002). "Rabies virus detection by RT-PCR in decomposed naturally infected brains". Veterinary Microbiology. 87 (2): 111–8. 1016/s0378-1135(02)00041-x. PMID 12034539. ^ Biswal M, Ratho R, Mishra B (September 2007). "Usefulness of reverse transcriptase-polymerase chain reaction for detection of rabies RNA in archival samples". Japanese Journal of Infectious Diseases. 60 (5): 298–9. PMID 17881871. ^ a b c d Ly S, Buchy P, Heng NY, Ong S, Chhor N, Bourhy H, Vong S (September 2009). Carabin H (ed. "Rabies situation in Cambodia". 3 (9): e511. PMC 2731168. PMID 19907631. e511. ^ Dürr S, Naïssengar S, Mindekem R, Diguimbye C, Niezgoda M, Kuzmin I, et al. (March 2008). Cleaveland S (ed. "Rabies diagnosis for developing countries". 2 (3): e206. PMC 2268742. PMID 18365035. e206. ^ a b "New Rapid Rabies Test Could Revolutionize Testing and Treatment | CDC Online Newsroom | CDC".. 16 May 2018. Retrieved 23 May 2018. ^ "Rabies: Differential Diagnoses & Workup". eMedicine Infectious Diseases. 3 October 2008. Archived from the original on 28 November 2010. Retrieved 30 January 2010. ^ Taylor DH, Straw BE, Zimmerman JL, D'Allaire S (2006). Diseases of swine. Oxford: Blackwell. pp. 463–5. ISBN 978-0-8138-1703-3. Retrieved 30 January 2010. ^ Minagar A, Alexander JS (2005). Inflammatory Disorders Of The Nervous System: Pathogenesis, Immunology, and Clinical Management. Humana Press. ISBN 978-1-58829-424-1. ^ Geison GL (April 1978). "Pasteur's work on rabies: reexamining the ethical issues". The Hastings Center Report. 8 (2): 26–33. 2307/3560403. JSTOR 3560403. PMID 348641. ^ Srivastava AK, Sardana V, Prasad K, Behari M (March 2004). "Diagnostic dilemma in flaccid paralysis following anti-rabies vaccine". Neurology India. 52 (1): 132–3. PMID 15069272. Archived from the original on 2 August 2009. ^ Reece JF, Chawla SK (September 2006). "Control of rabies in Jaipur, India, by the sterilisation and vaccination of neighbourhood dogs". The Veterinary Record. 159 (12): 379–83. 1136/vr. 159. 12. 379. PMID 16980523. ^ "Compendium of Animal Rabies Prevention and Control" (PDF). National Association of State Public Health Veterinarians. 31 December 2007. Archived from the original (PDF) on 12 July 2010. Retrieved 3 January 2010. ^ 2007 Annual Report (PDF) (Report). Bureau of Communicable Disease Control and Prevention. 2007. ^ "World Rabies Day". World Health Organization (WHO). Archived from the original on 31 December 2011. ^ Meltzer MI (October–December 1996). "Assessing the costs and benefits of an oral vaccine for raccoon rabies: a possible model". Emerging Infectious Diseases. 2 (4): 343–9. 3201/eid0204. 960411. PMC 2639934. PMID 8969251. ^ a b c Grambo RL (1995). The World of the Fox. Vancouver: Greystone Books. pp. 94–5. ISBN 978-0-87156-377-4. ^ "Rabies in the U. " Centers for Disease Control and Prevention (CDC). 22 April 2011. Archived from the original on 31 December 2011. Retrieved 31 December 2011. ^ a b Lite J (8 October 2008). "Medical Mystery: Only One Person Has Survived Rabies without Vaccine—But How? ". Scientific American. Archived from the original on 5 November 2009. Retrieved 30 January 2010. ^ "Human rabies: better coordination and emerging technology to improve access to vaccines". Archived from the original on 24 February 2017. Retrieved 23 February 2017. ^ "Use of a Reduced (4-Dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies" Archived 25 July 2011 at the Wayback Machine. Centers for Disease Control and Prevention (CDC). ^ "Cost of Rabies Prevention". 11 June 2019. Archived from the original on 29 March 2016. ^ Park's textbook of Community medicine, 22nd edition, 2013, p 254. ^ "Rabies".. Archived from the original on 15 February 2015. Retrieved 1 February 2015. ^ "Rabies & Australian bat lyssavirus information sheet". Archived from the original on 18 August 2011. Retrieved 30 January 2012. ^ National Center for Disease Control (2014). "National Guidelines on Rabies Prophylaxis" (PDF). Archived from the original (PDF) on 5 September 2014. Retrieved 5 September 2014. ^ De Serres G, Skowronski DM, Mimault P, Ouakki M, Maranda-Aubut R, Duval B (June 2009). "Bats in the bedroom, bats in the belfry: reanalysis of the rationale for rabies postexposure prophylaxis". Clinical Infectious Diseases. 48 (11): 1493–9. 1086/598998. PMID 19400689. ^ Despond O, Tucci M, Decaluwe H, Grégoire MC, S Teitelbaum J, Turgeon N (March 2002). "Rabies in a nine-year-old child: The myth of the bite". The Canadian Journal of Infectious Diseases. 13 (2): 121–5. 1155/2002/475909. PMC 2094861. PMID 18159381. ^ a b c d Jackson AC (November 2016). "Human Rabies: a 2016 Update". Current Infectious Disease Reports (Review). 18 (11): 38. 1007/s11908-016-0540-y. PMID 27730539. ^ Lite J (8 October 2008). "Medical Mystery: Only One Person Has Survived Rabies without Vaccine--But How? ". Retrieved 16 October 2008. ^ Willoughby Jr RE (April 2007). "A Cure for Rabies? ". 256 (4): 95. PMID 17479635. ^ Zeiler FA, Jackson AC (January 2016). "Critical Appraisal of the Milwaukee Protocol for Rabies: This Failed Approach Should Be Abandoned". The Canadian Journal of Neurological Sciences (Review). 43 (1): 44–51. 1017/cjn. 331. PMID 26639059. ^ a b "Rabies". September 2011. Retrieved 31 December 2011. ^ Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. (December 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". 380 (9859): 2095–128. 1016/S0140-6736(12)61728-0. hdl: 10536/DRO/DU:30050819. PMID 23245604. ^ Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. (April 2015). "Estimating the global burden of endemic canine rabies". 9 (4): e0003709. PMC 4400070. PMID 25881058. ^ "Rabies". Archived from the original on 15 February 2017. Retrieved 23 February 2017. ^ Dugan E (30 April 2008). "Dead as a dodo? Why scientists fear for the future of the Asian vulture". The Independent. London. Archived from the original on 17 May 2008. Retrieved 11 October 2008. India now has the highest rate of human rabies in the world. ^ a b Harris G (6 August 2012). "Where Streets Are Thronged With Strays Baring Fangs". New York Times. Archived from the original on 8 August 2012. Retrieved 6 August 2012. ^ Medicine challenges Indian superstition | Asia | | 31. 2012 Archived 31 January 2013 at the Wayback Machine ^ "Essential rabies maps" Archived 17 February 2010 at the Wayback Machine. World Health Organization (WHO). ^ a b Pieracci EG, Pearson CM, Wallace RM, Blanton JD, Whitehouse ER, Ma X, et al. (June 2019). "Vital Signs: Trends in Human Rabies Deaths and Exposures - United States, 1938-2018". MMWR. Morbidity and Mortality Weekly Report. 68 (23): 524–528. 15585/6823e1. PMC 6613553. PMID 31194721. ^ "CDC – Rabies Surveillance in the U. : Human Rabies – Rabies".. Archived from the original on 18 January 2017. Retrieved 10 April 2017. ^ Fox M (7 September 2007). "U. free of canine rabies virus". Reuters. Archived from the original on 17 May 2017. Retrieved 11 April 2017. "We don't want to misconstrue that rabies has been eliminated – dog rabies virus has been, " CDC rabies expert Dr. Charles Rupprecht told Reuters in a telephone interview. ^ "Rabies Surveillance Data in the United States". 12 July 2017. Archived from the original on 8 October 2011. ^ "SURVEILLANCE REPORT - Annual Epidemiological Report for 2015 - Rabies, ECDC (European Centre for Disease Prevention and Control)" (PDF). Retrieved 30 August 2018. ^ "Switzerland ended rabies epidemic by air dropping vaccinated chicken heads from helicopters / ". 20 November 2019. Retrieved 10 December 2019. ^ "Rabies in Africa: The RESOLAB network". Archived from the original on 3 August 2016. Retrieved 18 April 2016. ^ "Ministero della Salute: "Italia è indenne dalla rabbia". l'Ultimo caso nel 2011 - Quotidiano Sanità". Archived from the original on 3 June 2016. Retrieved 18 April 2016. ^ "Rabies". NHS. 23 February 2017. Retrieved 30 August 2018. ^ "Q&A: Rabies". BBC News. 17 April 2015. Retrieved 30 August 2018. ^ "Cómo México se convirtió en el primer país del mundo libre de rabia transmitida por perros". 12 November 2019. Retrieved 12 November 2019. ^ Adamson PB (1977). "The spread of rabies into Europe and the probable origin of this disease in antiquity". Journal of the Royal Asiatic Society of Great Britain & Ireland. Royal Asiatic Society of Great Britain and Ireland. 109 (2): 140–4. 1017/S0035869X00133829. JSTOR 25210880. PMID 11632333. ^ Dunlop RH, Williams DJ (1996). Veterinary Medicine: An Illustrated History. Mosby. ISBN 978-0-8016-3209-9. ^ Barrett AD, Stanberry LR (2009). Vaccines for Biodefense and Emerging and Neglected Diseases. p. 612. ISBN 9780080919027. Archived from the original on 28 April 2016. Retrieved 8 January 2016. ^ The Natural History of Rabies Archived 2 March 2016 at the Wayback Machine The first major epizootic in North America was reported in 1768, continuing until 1771 when foxes and dogs carried the disease to swine and domestic animals. The malady was so unusual that it was reported as a new disease ^ a b Rotivel Y. "Introduction". Federation of American Scientists. Archived from the original on 26 April 2009. Retrieved 25 April 2009. ^ Than K (27 October 2010). " " Zombie Virus" Possible via Rabies-Flu Hybrid? ". National Geographic. Archived from the original on 13 September 2015. Retrieved 13 September 2015. ^ Simpson DP (1979). Cassell's Latin Dictionary (5 ed. London: Cassell. p. 883. ISBN 978-0-304-52257-6. ^ Dalfardi B, Esnaashary MH, Yarmohammadi H (February 2014). "Rabies in medieval Persian literature - the Canon of Avicenna (980-1037 AD)". Infectious Diseases of Poverty. 3 (1): 7. 1186/2049-9957-3-7. PMC 3933285. PMID 24533686. ^ Ettinger SJ, Feldman EC (1995). Textbook of Veterinary Internal Medicine (4th ed. W. B. Saunders Company. ISBN 978-0-7216-6795-9. ^ Carpentier DC, Vevis K, Trabalza A, Georgiadis C, Ellison SM, Asfahani RI, Mazarakis ND (July 2012). "Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein". Gene Therapy. 19 (7): 761–74. 1038/gt. 2011. 124. PMID 21900965. ^ Roy A, Hooper DC (August 2007). "Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier". Journal of Virology. 81 (15): 7993–8. 1128/JVI. 00710-07. PMC 1951307. PMID 17507463. ^ Roy A, Phares TW, Koprowski H, Hooper DC (February 2007). "Failure to open the blood-brain barrier and deliver immune effectors to central nervous system tissues leads to the lethal outcome of silver-haired bat rabies virus infection". 81 (3): 1110–8. 01964-06. PMC 1797506. PMID 17108029. External links Classification D ICD - 10: A82 ICD - 9-CM: 071 MeSH: D011818 DiseasesDB: 11148 External resources MedlinePlus: 001334 eMedicine: med/1374 eerg/493 ped/1974 Patient UK: Rabies Orphanet: 770 Wikimedia Commons has media related to Rabies. Look up rabies in Wiktionary, the free dictionary. Rabies at Curlie "Rabies". Retrieved 12 August 2012. Virus Pathogen Database and Analysis Resource (ViPR): Rhabdoviridae OIE's Rabies Portal Aerophobia and Hydrophobia in Rabies Videos " Rabies virus ". NCBI Taxonomy Browser. 11292.
YouTube. “Hes bloody, what is he gonna do?” Idiot of 2019 😂🙄 bruh its rabid. Its gonna kill someone or some pet. If not already. Call the damn law. 
I LOVE the part when you went from amazement that a deer was circling in front of you in a parking lot until the split second you recognized he was foaming at the mouth and you ran like a little girl. Did you not maintain the vaccine. When he bit the zombie i died 😭😂. If you see a raccoon like this, call animal control. Proceeds recordings. Thanks a bunch for the help. Would have spent hours trying to find my way out of here without you! 👍👍👍✌️. 
Remaking a movie by a guy who was talented enough to create one of the great all-time remakes is ballsy and almost bound to fail. Rabid is close to being a good remake but has too many issues for my liking.
The story: a beautiful fashion designer has a life-changing accident and is doomed to a future of ugliness, unless she undergoes an experimental operation which has unforseen side-effects for her and the city around her. br> It's a cool premise, as was with the original but the pacing is way off. It takes too long to get off the ground and then when it does, lacks focus and seems to be telling two distinct stories rather than one, whereas Cronenberg's movie has a much sharper narrative.
There are a few grisly scenes but not immensly eye-opening for something that really should have people squirming.
The lead actress is good and, on the whole, the acting is solid but let down in a few places by some support roles. The editing could be a lot slicker; some scenes just felt dragged out and irrelevant.
I think it's worth checking out if you like the original but I'd be surprised if many people hail this as a big success.
Edit Storyline In Camelford, while swinging his van across a narrow road to make a u-turn, a driver stalls the vehicle that does not restart. Hart Read is driving his motorcycle with his girlfriend Rose and he drives off the road to avoid the collision. Hart suffers minor injuries while Rosie is injured and burned by the flames when the motorcycle explodes. The ambulance from the nearby Keloid Clinic for Plastic Surgery brings the couple and Rose, who is in coma, is submitted to an emergency surgery and to an experimental plastic-surgery technique by Dr. Dan Keloid to retrieve her skin in the chest and abdomen. Hart is discharged but Rose stays in coma in the intensive care unit (ICU) to recover. Out of the blue, Rose awakens from her coma one month later and screams. A nurse helps her but is wounded by her and then he cannot remember what has happened. He is sent to a hospital in Montreal while Rose realizes that she needs to feed with blood. However her victims become zombie-like creatures. Rose... Written by Claudio Carvalho, Rio de Janeiro, Brazil Plot Summary | Plot Synopsis Taglines: Pray it doesn't happen to you. See more » Details Release Date: 8 April 1977 (USA) Box Office Budget: CAD530, 000 (estimated) See more on IMDbPro » Company Credits Technical Specs Color: Color (Eastmancolor) See full technical specs » Did You Know? Trivia A poster for Carrie (1976) is visible after Rose walks out of the porn theatre. Sissy Spacek, who played Carrie in that film, was the first choice for Rose but was turned down because of her Texas accent. See more » Goofs At the ten minute mark, the doctor takes a skin graft from Roses leg, when we see him peel the graft off, it's clearly 5 or 6mm wider than the wound it's taken from, almost like a piece of latex or cloth being peeled off the wound. See more » Quotes Murray Cypher: Potato man loves ketchup man. Alternate Versions All UK DVD versions are missing around 20 secs of footage from a conversation between the 2 male leads and a policeman in a parking lot. The edits were not made by the BBFC and appear to have been a result of print damage. See more » Connections Referenced in Alien (1979) Soundtracks Vulcain from album "Energie" Composed by Caravelli See more ».
That's the farthest lean back I ever seen. Yeah it was in a Fox News. Ngl i hate this game.
directors Frank Perozo.
Verga le e dado me gusta sin verla 🤣 pero como que me va a gustar 😁. Eu acho que é montagem Como ele ia chegar tão perto sem eles ô atacar. Los leones 2020. Los leones park. Los leones 2. La ley de la selva muy interesante y AL FIN un narrador con buena voz👍.
Pobre Dumbo. Los leones pelicula completa en español ozuna. Feliz semana que sea llena de bendiciones y gracisas por compartir este repaso. Los leones fine arts. Los leones del norte la muerta. Los leones de la sierra. Los lonesome. 
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No America didn't create freedom. Download Full Jump Shot: The Kenny Sailors story 4. There was just one witness to the moment Kenny Sailors helped revolutionize the game of basketball — his brother, Bud — but by all accounts no one has ever doubted their story. The moment came on a hot May day in 1934. The two were tussling, one on one, under an iron rim nailed to the side of the family's windmill, a wood-shingled, big-bladed landmark that their neighbors on the Wyoming high plains recognized for miles around the way sailors of the usual kind know a lighthouse from miles out at sea. Kenny, a 13-year-old spring-legged featherweight, was dribbling this way and that on the hardpan, trying to drive to the basket, when Bud began taunting him, as older brothers will. "Let's see if you can get a shot up over me, " Bud said. A high school basketball standout, he had five years on his brother and, at that time, almost a foot in height. Kenny took the challenge, doing what people at a disadvantage often do: He improvised. He squared up, planted his feet and leaped. "I had to think of something, " he said in an interview a lifetime later. What he thought of was the jump shot, an innovation that would eventually be seen as comparable to the forward pass in football. Kenny Sailors, who spent more than 30 years in Alaska as a coach and big-game hunting guide, died at 95 on Saturday in Laramie, Wyoming. Sailors would never say flat out that he had invented the jump shot. No one can say for sure who did. The early 20th century produced enough far-flung claimants to that distinction to fill out a starting five and warm a decent-size bench — players like Glenn Roberts, Bud Palmer, Mouse Gonzalez, Jumpin' Joe Fulks, Hank Luisetti and Belus Van Smawley. But people of reliable authority have said that if you had to pick the one whose prototypical jump shot was the purest, whose mechanics set in motion a scoring technique that thrilled fans and helped transform a two-handed, flat-footed, essentially earthbound affair into the vertical game it is today, giving rise, quite literally, to marksmen like Oscar Robertson, Jerry West, Rick Barry, Michael Jordan and Kobe Bryant, it would be Sailors. Sailors developed the shot in high school, perfected it in college as a three-time All-American and was one of the few of his era to make a living off it in the professional ranks. He did so in the face of skeptics. The game back then was all about quick passing to find the open man and shooting from the chest, with two hands, feet on the floor. Watching Sailors play, a coach told him, "You gotta get yourself a good two-hand set shot, " and benched him. But Sailors, ever the freewheeler, ignored the advice, to the delight of fans in Laramie, where, as the point guard, he led the University of Wyoming Cowboys on an improbable ride to their only NCAA championship, in 1943, making the college powerhouses of the East and the big-city reporters who covered them sit up and take notice of Western basketball. If anyone can be said to have immortalized Sailors, it was Life magazine photographer Eric Schaal. He was courtside at Madison Square Garden in January 1946, when, in a game between Wyoming and Long Island University, his camera caught Sailors airborne. In the picture Sailors, in black high-tops, is suspended a full yard above the hardwood and at least that much over the outstretched hand of his hapless defender. The ball is cradled above his head, elbow at 90 degrees, his right hand poised to fling the shot with a snap of the wrist that will have it backspinning to the rim along a high arc. The photograph, appearing in one of America's widest-circulating magazines, made an impact coast to coast. "A shot whose origins could be traced to isolated pockets across the country — from the North Woods to Ozarks, from the Appalachian Mountains to the Pacific — was suddenly by virtue of one picture as widespread as the game itself, " journalist John Christgau wrote in his book "The Origins of the Jump Shot. " "Everywhere young players on basketball courts began jumping to shoot. " As the book's subtitle acknowledges — "Eight Men Who Shook the World of Basketball" — the jump shot had many fathers, all within a few years of one another, suggesting that in the long evolution of the game its time had ineluctably come. Each inventor had his own variation. Van Smawley, with his back to the basket, would corkscrew around to face the hoop before releasing the ball. Luisetti's was a running one-hander. But Christgau picked Sailors' technique as the one modern fans would recognize. "I would say that squared up toward the basket, body hanging straight, the cocked arm, the ball over the head, the knuckles at the hairline — that's today's classic jump shot, " Christgau said in an interview. "It was unblockable. " That view was echoed by Jerry Krause, research chairman of the National Association of Basketball Coaches. His own study, he told in 2015, led him to conclude that Sailors was the first player to develop and use the shot consistently. Basketball eminences have also given Sailors their vote. Joe Lapchick, former NBA star and coach, wrote in 1965, "Sailors started the one-handed jumper, which is probably the shot of the present and the future. " And Ray Meyer, the venerated coach of DePaul University, assured Sailors in a handwritten letter, "You were the first I saw with the true jump shot as we know it today. " Kenneth L. Sailors was born on Jan. 14, 1921, in Bushnell, Nebraska, (population 124), to Edward Sailors and the former Cora Belle Houtz. His mother had gone west in a covered wagon and grown up in a sod house. She gave birth to Kenny by herself. The parents divorced when the boys were young, and Ken and Bud — Barton on his birth certificate — were reared by their mother on a 320-acre farm outside Hillsdale, a stockyard town in southeastern Wyoming. An older sister, Gladys, had married and left home. The boys helped keep the farm going through the Depression, driving to Cheyenne, the state capital, to sell potatoes, bantam sweet corn and chickens. One year they raised hogs, butchered them and sold the meat door to door from a trailer hitched to an old Chevy. As they headed for school in the morning, the boys would see their mother out in the fields, and when they came home in the afternoon, they'd see her there still. The brothers' historic game of one on one remained vivid in Kenny Sailors' memory. "The good Lord must have put in my mind that if I'm going to get up over this big bum so I can shoot, I'm going to have to jump, " he said in an interview on NPR in 2008. "It probably wasn't pretty, but I got the shot off, and it went in. And, boy, Bud says: 'You'd better develop that. That's going to be a good shot. ' And I started working on it. " Bud was an All-Stater, and when he received a basketball scholarship from the University of Wyoming in Laramie, his mother sold the farm, pulled Kenny out of high school and moved there, too, opening a boardinghouse. Kenny became a champion miler and long jumper and a basketball star at Laramie High School, building leg power that would eventually give him, by his measure, a 36-inch vertical lift — an invaluable asset for a 5-foot-10 point guard. The jump shot puzzled the Laramie coach, Floyd Norman. "Where'd you get that queer shot? " Kenny Sailors recalled him asking. Sailors led the Laramie Plainsmen to a state championship and followed his brother to the University of Wyoming, also on a scholarship. (Early on he was a teammate of future sports broadcaster Curt Gowdy). He soon had sports writers groping to describe his jump shot. "A shot-put throw, " one wrote. Chester Nelson, a sports writer for The Rocky Mountain News in Colorado known as Red, wrote of Sailors in 1943: "His dribble is a sight to behold. He can leap with a mighty spring and get off that dazzling one-handed shot. Master Kenneth Sailors is one of the handiest hardwood artists ever to trod the boards. " In the 1942-43 season, under coach Everett Shelton, Sailors led the team to a 31-2 record and Wyoming's only national championship, defeating Georgetown, 46-34, at Madison Square Garden. Sailors was chosen the tournament's most outstanding player. "His ability to dribble through and around any type of defense was uncanny, just as was his electrifying one-handed shot, " The New York Times said. Wyoming was anointed the nation's best college team after it defeated St. John's University, the National Invitation Tournament champion, 52-47, in overtime in a Red Cross fundraising exhibition at the Garden on April 1, 1943. "The dynamic Ken Sailors, " as The Times put it, led the way again. That year he married Marilynne Corbin, a cheerleader nicknamed Bokie, then enlisted in the Marines and served in the South Pacific, where Bud was flying B-25 bombers. Discharged in 1945 with a Bronze Star and captain's bars, Kenny Sailors, with a year of eligibility left, rejoined the Wyoming team midseason and led it to a 22-4 record, earning his third All-America honor and a contract with the Cleveland Rebels of the Basketball Association of America. The jump shot was still alien to the pros, and the Rebels' coach, Dutch Dehnert, was skeptical. "You'll never go in this league with that shot, " he told Sailors before benching him. But Dehnert was soon gone in a coaching change and Sailors, with his jump shot, returned to the lineup. He was named a second-team All-Pro in his rookie season. Professional stardom eluded him, though. In three seasons in the BAA and two in its successor, the National Basketball Association, he played mostly on losing teams, like the Providence Steamrollers in Rhode Island (where he signed an endorsement deal with Bennett's Prune Juice, receiving all-you-can-drink cases of it as a bonus). He led the original Denver Nuggets in scoring one year, exploded for 37 points in a game with the Baltimore Bullets, and finished with the Boston Celtics, retiring from professional basketball at 30. Sailors later bought a dude ranch in Jackson Hole, Wyoming. A Republican, he served a term in the Wyoming Legislature and lost two bids for the House of Representatives and another for the Senate. With their children grown, Sailors and his wife sold the ranch to his brother in 1965, packed up and drove to Alaska, living at first in an Airstream trailer. They stayed for more than 30 years, moving to a log cabin in Gakona, overlooking the Copper River, and then to Angoon on Admiralty Island. Sailors led hunting and fishing expeditions, coached youth and high school basketball and taught high school history. After Marilynne Sailors developed Alzheimer's disease, the couple moved to Idaho, following their daughter Linda, who had married. Marilynne died in 2002 after 59 years of marriage, after which Sailors moved back to Laramie and settled near the university as a living campus legend. Plans were afoot to erect a statue of him at the basketball arena's entrance. To the disappointment of his fans, the Naismith Memorial Basketball Hall of Fame in Springfield, Massachusetts, has never inducted him. But the National Collegiate Basketball Hall of Fame did, in 2012, in a class that included Patrick Ewing, Earl Monroe and Willis Reed. Sailors joined his coach Everett Shelton among the enshrined. Days afterward, the University of Wyoming honored Sailors with a halftime ceremony during a game against Colorado. Overhead was a familiar sight, a Gulliver-size Cowboys jersey hanging from the roof, its downy white trimmed in brown and gold and bearing Sailors' name and number, 4. It remains the only jersey suspended there, high above the court. Correction: An earlier version of this story inaccurately called Sailors a former Glennallen resident. He coached in Glennallen? but lived in Gakona.
I noticed they did not mention at all he was a pastor a man of God. It was invented in Canada. Basketball was invented in Canada so for you Americans put that in your pipe and smoke it.
Download Full Jump Shot: The Kenny Sailors story 7. 
This guy got the history wrong because first of all it was made in canada and second of all coloured people coudnt play basketball at that time. Really humbling, good for you Mr. Sailors! One more person knows about your feat. That was awesome. Download Full Jump Shot: The Kenny Sailors storyid.
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